EXPLAINER

Brown fat burns calories to make heat. Can adults get more of it?

Scans confirmed that adults keep heat-producing brown fat, switched on by cold and linked to better metabolic health. Whether you can build enough of it to matter for weight is far less certain.

Adults with detectable active brown fat: mild cold versus a warm roomMild cold (16°C): 96%; Thermoneutral (22°C): 0%0%50%100%Mild cold (16°C)96%Thermoneutral (22°C)0%
Adults with detectable active brown fat: mild cold versus a warm room
GroupValue (%)
Mild cold (16°C)96
Thermoneutral (22°C)0
Adults with detectable active brown fat: mild cold versus a warm room 24 healthy men imaged at 16°C and at 22°C. Active brown fat appeared during cold in 23 of the 24 men and in none of them in the warm room. Source: New England Journal of Medicine

Brown fat is a type of body fat that burns energy to produce heat instead of storing it, and a run of imaging studies since 2009 confirmed that adults keep working deposits of it — mostly in the neck and upper chest — that switch on in the cold [s1] [s2]. People who have detectable brown fat tend to be metabolically healthier, but the leap from that association to "activate your brown fat and lose weight" is where the evidence thins out, and the honest answer is that whether adults can recruit enough of it to matter for body weight is still unsettled [s3] [s4].

What brown fat does

Ordinary white fat stores surplus energy. Brown and "beige" fat do the opposite: their cells are packed with mitochondria that express a protein called uncoupling protein 1, or UCP1, which short-circuits the normal energy-producing machinery so that the reaction throws off heat rather than storing chemical energy [s1]. It is how newborns and hibernating mammals stay warm without shivering. Textbooks long held that this tissue faded to insignificance after infancy in humans.

That assumption broke in 2009. Using 18F-fluorodeoxyglucose PET-CT scans — imaging that lights up metabolically active tissue — one study reviewed 3,640 scans in 1,972 patients and found active brown fat in 76 of 1,013 women (7.5%) and 30 of 959 men (3.1%), confirmed as genuine brown fat by UCP1 staining of biopsy tissue [s1]. The chance of detecting it fell with age, with warmer outdoor temperature at the time of the scan, with beta-blocker use, and — in older patients — with higher body-mass index [s1].

Cold is the switch

A companion study made the trigger explicit. Researchers imaged 24 healthy men, 10 lean and 14 overweight or obese, first in a warm room at 22°C and then during mild cold exposure at 16°C [s2]. Active brown fat appeared during cold in 23 of the 24 men — about 96% — and in none of them in the warm room [s2]. Activity was significantly lower in the overweight and obese men than in the lean men (P = 0.007), and the amount of brown fat correlated inversely with body fat [s2]. This is why the tissue was missed for so long: routine scans are done in warm rooms, where brown fat is quiet.

The health association — and its limits

The largest human dataset came in 2021, when researchers categorised 134,529 PET-CT scans from 52,487 patients by whether brown fat was visible [s3]. People with detectable brown fat had lower odds of type 2 diabetes, abnormal cholesterol, coronary artery disease, cerebrovascular disease, congestive heart failure and high blood pressure, and the apparent benefit was larger in people with overweight or obesity [s3]. That is a striking correlation, but it is a correlation: the scans were done for cancer care, not randomly, and the study cannot show that brown fat caused the better health rather than tracking something else, such as youth, leanness or cold tolerance [s3].

Can you build more of it?

This is the question the wellness market has run ahead of, with cold plunges and ice baths sold partly on the promise of stoking brown fat. There is a real experiment behind the idea, but a small one. In a 2013 study, healthy volunteers with low starting brown-fat activity underwent daily two-hour cold exposure at 17°C for six weeks; their brown-fat activity and cold-induced energy expenditure rose in parallel, and their body-fat mass fell [s4]. A separate arm found that six weeks of ingesting capsinoids, non-pungent chilli compounds, similarly raised cold-induced energy expenditure [s4]. The authors concluded that brown fat can be recruited even in people who start with little [s4].

The caveats are large. These were small, short studies of a demanding regimen — two hours of cold daily is not a plunge — and they measured brown-fat activity and body composition, not long-term weight or cardiovascular outcomes [s4]. The energy a realistic amount of brown fat burns is modest, and no trial has shown that cold exposure produces meaningful, durable weight loss in the way diet or the newer obesity drugs do.

Where the science stands

Brown fat is real, it persists into adulthood, it is switched on by cold, and having it tracks with better metabolic health [s1] [s2] [s3]. It can be coaxed to grow, at least a little, with sustained cold or certain compounds [s4]. What has not been shown is that anyone can build enough of it, easily enough, to make it a weight-loss strategy — which is exactly the claim the ice-bath marketing leans on. As a target for future obesity or diabetes drugs, brown fat is a serious lead; as a reason to sit in cold water, it is still running well ahead of its evidence.

Sources

  1. Identification and Importance of Brown Adipose Tissue in Adult Humans — New England Journal of Medicine , April 8, 2009
  2. Cold-Activated Brown Adipose Tissue in Healthy Men — New England Journal of Medicine , April 8, 2009
  3. Brown adipose tissue is associated with cardiometabolic health — Nature Medicine , January 4, 2021
  4. Recruited brown adipose tissue as an antiobesity agent in humans — Journal of Clinical Investigation , July 15, 2013

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