For how we live.
A 96,000-woman registry emulation found pre-conception GLP-1 or GLP-1/GIP therapy in PCOS tracked with lower pregnancy risk than metformin. It is not a trial, and says nothing about use during pregnancy.
Randomised trials show a Palaeolithic diet trims weight and risk markers in the short term. A two-year trial found the early edge over an ordinary healthy diet had mostly faded — and that people struggled to stick to it.
Triglycerides are the lipid panel's fourth number, and most of what raises them is modifiable. Here is where the thresholds sit — and the point at which a very high level becomes a medical emergency.
Scans confirmed that adults keep heat-producing brown fat, switched on by cold and linked to better metabolic health. Whether you can build enough of it to matter for weight is far less certain.
For heart disease and death, dairy looks roughly neutral to modestly favourable in large cohorts, and the long-standing warning against whole-fat dairy is not well supported by outcome data.
A twins trial found a vegan diet lowered LDL cholesterol, insulin and weight in eight weeks. The same pattern comes with real gaps — vitamin B12 must be supplemented, and iron stores tend to run lower.
The PERTH trial is a 60-person pilot, and its outcome was urinary chemistry rather than health. Within those limits it answered a question people keep asking.
In a 618-person randomized trial, 27.8% of the intervention group met the sustained-remission endpoint at 24 months against 21.2% of comparators. The confidence interval nearly touches no effect.
An Oxford meta-analysis of 37 studies puts average regain at 0.4 kg a month across all weight-management drugs, and 0.8 kg a month for semaglutide and tirzepatide. Almost none of the newer-drug data runs past a year.
A UK Biobank analysis of 96,365 people found a dose-response relationship between lifetime night-shift exposure and cardiovascular-kidney-metabolic disease — amplified in those who also slept short.