For how we live.
A prospective, quasi-experimental study links the air-quality gains after China's 2013 Clean Air Act to an average 6.6-percentage-point reduction in predicted cardiovascular risk.
In 2.5 million Swedish births followed to adulthood, mothers' early-pregnancy obesity was linked to a stepwise rise in offspring cardiovascular disease, though sibling analyses temper the size.
In 7,530 people from two long-running cohorts, central sleep apnea with high oxygen overshoot carried elevated cardiovascular risk. The same apnea with low overshoot did not.
The REACT study imaged people aged 18 to 70 with no known cardiovascular disease. Atherosclerosis was already present in some people in their twenties, and it was usually in the legs, not the heart.
A Chinese cohort found serum PCBs associated with a higher calculated 10-year cardiovascular risk. The longitudinal results did not survive correction for multiple testing, and no events were counted.
A first-in-human trial of Kylo-11 reports 97% reduction at 48 weeks after a single dose. A lepodisiran analysis reports near-total clearance of the oxidised phospholipids Lp(a) carries.
WHO and ILO estimate about 17% of workers face hazardous noise. Their review of whether it causes heart disease found only low-certainty signals — one for heart-attack incidence, little for stroke or blood pressure.
A trial of an anti-inflammatory antibody cut cardiovascular events without changing lipids. A genetic study of 194,418 people found the inflammation marker everyone measures is not itself causal.
Leisure exercise reliably protects the heart. Physical activity done for a living shows mixed or even adverse associations — and some meta-analyses find higher mortality in men with the most physically demanding jobs.
The IARC calls night shift work probably carcinogenic. A 2026 meta-analysis of nurses shows why 'probably' is careful: the breast cancer signal appears only after decades, and shrinks to nothing once bias is corrected.
A meta-analysis of 45 cohorts found risk rising steadily with every 10 beats per minute. A study of 92,457 wearable users found one person's normal can differ from another's by 70 beats.
A Cochrane review of 11 trials found flight stockings sharply cut silent deep-vein clots. But across nearly 2,900 passengers, the trials recorded no pulmonary embolism, death, or symptomatic clot at all.
Genetic and trial evidence establishes LDL as causal for atherosclerosis. The same kinds of evidence, applied to HDL, found that raising it does not lower heart attack risk.
American guidelines call 130/80 stage 1 hypertension. European ones call the same reading elevated blood pressure and not yet disease. The measurement did not change. The label did.
Both morning and evening chronotypes showed elevated risk against the middle ground, and the effect nearly doubled in people who also had sleep apnea.
In 377 patients, hypoxic burden — a metric combining how often, how deep, and how long oxygen drops — tracked with abnormal nighttime blood pressure patterns where conventional measures didn't.
A Qatar Biobank analysis derived local cut-points and found WHO's standard numbers misclassified more than half of men and nearly half of women in the sample.
A 20-point rise in apnea severity tracked with about three times more blood pressure increase in adults with a BMI of 20 than in those with a BMI of 30, flipping a common assumption.
Researchers deliberately withdrew CPAP for three nights to simulate untreated sleep apnea, then tested propranolol against placebo. It slowed the heart-rate surges tied to apnea events, at the price of lighter sleep.
A UK Biobank analysis finds high step counts do not offset short sleep. A US cohort finds one-minute bursts matter. And in older adults, most step-count differences vanish after adjusting for age and sex.
Carriers of loss-of-function MC4R mutations had lower LDL and triglycerides than UK Biobank controls of similar adiposity, and lower cardiovascular risk. The brain sets body weight and lipids separately.