For how we live.
In 415,000 New Jersey births, infants of mothers who screened positive for depression died before age one at more than three times the rate, an association steady across race, income and preterm birth.
13% of women met criteria for insomnia disorder six weeks after delivery, and only two had been evaluated. In a separate cohort, restless legs in pregnancy tripled the risk of perinatal depression.
Two large re-analyses of the same public datasets found the association is real, negative and very small. A third review found the association is not even consistent between the Global North and South.
A Lancet review triangulates the evidence linking adiposity to multisystem disease and finds robust trial support in a short list — while an expert panel argues the drugs must be lifelong.
In 1,238 people from two community cohorts, apnea severity showed no link to depressive symptoms. Sleep fragmentation did, and that association disappeared once insomnia symptoms entered the model.
The ODDESSI trial ran in 30 clusters across five NHS trusts in England. Time to relapse was unchanged; inpatient admission, re-referral and service-user ratings all moved in Open Dialogue's favour.
The committee that decides what Israel's national insurance covers added new cancer and depression drugs to the 2026 list — and turned down an early Alzheimer's treatment because of what it would have cost.
Under-25s lost about 5 points on a 100-point wellbeing scale between 2019 and 2021. Adults 19 to 24 have clawed back two-thirds of that loss. Teenagers 15 to 18 have recovered barely a third.
Users were slightly less likely than non-users to attempt suicide in the two to four years after treatment. The FDA's 2005 boxed warning stands, and the analysis cannot explain the direction of the finding.
A network meta-analysis of 331 trials and 34,285 adults found no significant differences between the main psychotherapies, with one exception. In children and adolescents the picture is narrower.
A million-woman Danish cohort found a modest rise in antidepressant use among hormonal contraceptive users. A Cochrane review of weight found no evidence the pill causes weight gain.
A network meta-analysis of 101 trials and 11,910 patients found no significant difference between psychotherapy and medication for adult depression — and a consistent advantage for combining them.
A review of 110 studies found that 52% of trialled self-guided apps were publicly available — and that evidence quality had no bearing on which ones made it to an app store.
A systematic review found only 16 usable studies of how to implement routine symptom monitoring in adult mental health services. A 4,778-patient clinic dataset shows what it looks like when it does.
A meta-analysis of six studies found a moderate effect on sleep duration and a small one on depressive symptoms — with high heterogeneity on both.
Tirzepatide and semaglutide showed comparable psychiatric risk profiles against each other over two years. Against earlier GLP-1 drugs, semaglutide came out ahead on all three measures.
Stress peaked during the fasting month and fell afterwards, but depression and anxiety stayed flat. The consistent finding across every phase was that sleep quality tracked mental health.
A registered report fit identical models to 11 longitudinal studies covering 175,070 people. The subjective feeling carried the signal; the objective count of social contacts largely did not.
A burden-of-disease calculation built on EU noise-mapping data puts numbers on two outcomes that noise research has mostly ignored. The confidence intervals are as informative as the estimates.
A Danish registry study of 136,842 women found elevated antidepressant and anxiolytic prescribing in the decade preceding diagnosis, with psychiatric hospital contacts rising about five years before.
A systematic review screened 3,857 records and found three eligible studies, every one produced by a US commercial provider and every one at critical risk of bias.
The first large-scale policy evaluation of medically tailored meals covers 1,866 recipients across 11 health systems. It is quasi-experimental, not randomised — and that is the finding's main limit.
A cross-sectional analysis of NICE evaluations found 78 supporting studies behind 30 technologies — and consistent holes in comparators, cost of delivery and adverse-event reporting.
A secondary analysis of 8,376 adolescents built two models to predict who benefits from school-based mindfulness training. Both found a subgroup — and the difference in outcomes was trivial.
The barriers parents named most often were cost and the absence of any nearby service — not stigma, which the field has spent years treating as the main obstacle.
A survey-based analysis of the European Health Interview Survey puts a price on Europe's obesity-related hospital use, and finds the strongest single association is not with obesity at all.
Australian teenagers harmed by the Black Summer fires showed no elevated depression, anxiety, distress, insomnia or suicidality two years later. The result runs against a systematic review published months earlier.
Pooling 94 cohort studies, grip strength tracked with later dementia, depression and disability. The authors rate their own confidence in the numbers as limited to moderate.
A 1,151-person Hong Kong trial used trained lay counsellors, not clinicians, and no internet. The effect sizes are small, and the authors are explicit that they do not know whether it travels.
Seventy-three trials, and a familiar pattern: the benefit versus no treatment shrinks by a third when only the best-conducted studies are counted. The head-to-head comparisons rest on a few hundred people.
Among 16-to-24-year-olds in NHANES, those who slept longer on weekends had 41% lower odds of daily depressive symptoms. The survey measured both at the same moment, which limits what can be concluded.
A meta-analysis of eleven depression trials found an average effect below the threshold for clinical importance, with signs of bias favouring creatine. A separate review found no change in kidney filtration.
Intimate partner violence has declined by 0.2% a year over two decades. The report also produces the first national and regional estimates of sexual violence by someone other than a partner.
Pooling 151 studies and 58,534 participants across 30 drugs, researchers ranked antidepressants by physiological side effects rather than efficacy. Some drugs raised cholesterol while reducing body weight.
Age-standardised disability-adjusted life-years fell 12.6% since 2010, but the raw total rose 6.1% to 2.80 billion. Anxiety, depression and diabetes rose fastest even after adjusting for ageing.
Loneliness tracked with depression, perceived stress, psychotic-like experiences and suicidal ideation. A prevalence that high raises a question about what the measure is capturing.
The guidance is built on one negative instruction: do not stop abruptly in patients likely to be physically dependent. Hong Kong records show the sharpest prescribing rise in 18-to-25-year-olds.
Seventeen longitudinal studies of young carers, all from high-income countries. And 247 studies of women in prison, nearly all at high risk of bias in at least one domain.