For how we live.
Under-25s lost about 5 points on a 100-point wellbeing scale between 2019 and 2021. Adults 19 to 24 have clawed back two-thirds of that loss. Teenagers 15 to 18 have recovered barely a third.
A review of 110 studies found that 52% of trialled self-guided apps were publicly available — and that evidence quality had no bearing on which ones made it to an app store.
Tirzepatide and semaglutide showed comparable psychiatric risk profiles against each other over two years. Against earlier GLP-1 drugs, semaglutide came out ahead on all three measures.
Stress peaked during the fasting month and fell afterwards, but depression and anxiety stayed flat. The consistent finding across every phase was that sleep quality tracked mental health.
A registered report fit identical models to 11 longitudinal studies covering 175,070 people. The subjective feeling carried the signal; the objective count of social contacts largely did not.
A Danish registry study of 136,842 women found elevated antidepressant and anxiolytic prescribing in the decade preceding diagnosis, with psychiatric hospital contacts rising about five years before.
A systematic review screened 3,857 records and found three eligible studies, every one produced by a US commercial provider and every one at critical risk of bias.
Anxiety, quality of life and PTSD symptoms all improved after a single dose in this 15-person trial. Once researchers accounted for depression improvement, those effects mostly disappeared.
A cross-sectional analysis of NICE evaluations found 78 supporting studies behind 30 technologies — and consistent holes in comparators, cost of delivery and adverse-event reporting.
A secondary analysis of 8,376 adolescents built two models to predict who benefits from school-based mindfulness training. Both found a subgroup — and the difference in outcomes was trivial.
The barriers parents named most often were cost and the absence of any nearby service — not stigma, which the field has spent years treating as the main obstacle.
Australian teenagers harmed by the Black Summer fires showed no elevated depression, anxiety, distress, insomnia or suicidality two years later. The result runs against a systematic review published months earlier.
A 1,151-person Hong Kong trial used trained lay counsellors, not clinicians, and no internet. The effect sizes are small, and the authors are explicit that they do not know whether it travels.
Age-standardised disability-adjusted life-years fell 12.6% since 2010, but the raw total rose 6.1% to 2.80 billion. Anxiety, depression and diabetes rose fastest even after adjusting for ageing.
The guidance is built on one negative instruction: do not stop abruptly in patients likely to be physically dependent. Hong Kong records show the sharpest prescribing rise in 18-to-25-year-olds.
Seventeen longitudinal studies of young carers, all from high-income countries. And 247 studies of women in prison, nearly all at high risk of bias in at least one domain.