Which muscles hold their strength through weight loss? A gene hunt
A transcriptomic sub-study of the CALERIE calorie-restriction trial links 151 genes to preserved leg strength during weight loss, independent of how much body mass was lost.
Each 30 minutes of weekly aerobic exercise produced half a kilogram of weight loss
A meta-analysis of 116 randomised trials found weight, waist and body fat falling steadily up to 300 minutes a week. In one 24-week trial, 48% of participants compensated by about 308 kcal a day.
Fatty liver disease affects roughly a third of adults. Weight loss is what reverses it.
MASLD is excess fat in the liver unrelated to alcohol, and about 30% of adults have it. The best-evidenced way to reverse the inflamed form is weight loss — and how much you lose tracks how much the liver recovers.
Six months of intermittent fasting: 8% weight loss, better lipids, and not much else
The trial's own primary outcome — inflammation — was flat. What the new analysis adds is a molecular account of why the fat loss did not translate into the benefits fasting is sold on.
Cutting calories on top of a Mediterranean diet lowered diabetes risk by 31%
A Spanish trial in 4,746 adults compared an energy-reduced Mediterranean diet plus exercise against the same diet eaten freely. Over six years the absolute gap was 12.0% versus 9.5%.
Same healthy-eating guidance, two versions: the less processed one lost more weight
Fifty-five English adults ate two eight-week diets that both followed the UK Eatwell Guide. Both produced weight loss. The minimally processed version produced about one percentage point more.
99 trials of intermittent fasting: the differences between methods are small
A BMJ network meta-analysis of 6,582 adults finds alternate day fasting the only intermittent method that beat continuous calorie restriction — by 1.29 kg, mostly in short trials.