For how we live.
Sold as natural, safer and tailored by hormone testing, custom-compounded menopausal hormones are untested against approved options — and expert panels advise restricting their use.
A 4,153-woman trial found progesterone did not raise live births overall. The benefit concentrated in women who were bleeding and had had three or more previous miscarriages.
Six products got revised labels in February 2026, removing cardiovascular, breast cancer, and dementia language. The scientific societies that welcomed the change also listed the distinctions the new label does not make.
A 444,000-patient records study found a two-thirds lower rate of endometrial cancer when GLP-1 receptor agonists were added to progestin therapy. The two groups differed by eight years in average age.