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Screening 2,904 proteins in early pregnancy, researchers found low maternal isthmin-2 was the strongest signal for later preeclampsia or fetal growth restriction, validated in two cohorts.
Among 603 RECOVER participants, 118 were classified as likely having Long COVID. The primary analysis found no association with preterm delivery, and one secondary signal that only appeared in a sensitivity analysis.
Pooling under 11,000 pregnancies, a meta-analysis found no statistically significant association either way, with the three underlying studies disagreeing on which direction the risk even points.
A Finnish registry of over 123,000 women found pre-eclampsia linked to an 11% lower breast cancer risk decades later. Hormone therapy raised risk by a similar amount in both groups.
A Global Burden of Disease comparison puts the 2023 US maternal mortality rate at 33.8 per 100,000 live births, alongside cardio-kidney-metabolic risk burdens several times those of other high-income countries.
The 27 recommendations cover monitoring, diet and medication for type 1, type 2 and gestational diabetes. WHO had guidance on diabetes and guidance on pregnancy, but never on the two together.
The 162 mg group had 14.1% preterm or severe preeclampsia against 17.1% on 81 mg — a difference the trial could not distinguish from chance. Eight placental abruptions occurred on the higher dose and none on the lower.