For how we live.
A bird-flu virus from British Columbia poultry carried the H275Y mutation that blunts Tamiflu and peramivir. In the lab it stayed vulnerable to zanamivir and baloxavir — and was less virulent in mice.
The two most-prescribed respiratory antivirals sit at opposite ends of the evidence. One shortens flu by less than a day on average; the other cut serious outcomes sharply — but only in the group at real risk.
An 8-year-old boy had brain inflammation with no respiratory symptoms. Every respiratory, blood and rectal sample tested negative; the virus was in his cerebrospinal fluid alone.