For how we live.
In the 17,701-person E.mbrace trial in adults 60 and older, the nine-valent ExPEC9V vaccine showed 14.63% efficacy, with a confidence interval spanning zero. It stopped early for futility; development is discontinued.
The FDA logged the recall of 2,718 Medline convenience kits on 23 September: sterile applicators in some lots could grow the mould Aspergillus penicillioides, and contaminated skin-prep risks infection or sepsis.
In the SNAP platform trial, cefazolin was non-inferior to flucloxacillin or cloxacillin for 90-day survival in methicillin-susceptible S. aureus bacteraemia, and caused notably less acute kidney injury.
Across 41 hospitals in 19 Asian countries, ACORN-HAI found 73.7% of severe bloodstream and ventilator infections were drug-resistant, and 37.7% of those patients died within 28 days.
The system sorts feverish under-5s into red, amber and green. Validation studies find it misses serious illness and over-refers the well — a prompt, not a reliable test.
Sepsis is the body's own response to an infection turning against its organs. It kills an estimated 11 million people a year, and the evidence keeps pointing to how fast it is caught and treated.
A network meta-analysis of 53 studies and more than 7 million admissions finds machine learning out-discriminates traditional sepsis scores — and would raise roughly two false alarms for every real one.
Across 26 states, expansion raised the Medicaid-paid share of deliveries by 5.2% and changed the severe maternal morbidity rate by 0.02% — an interval that includes zero in both directions.
The tool reads vital signs, lab results, and history the way clinicians already do — just faster and continuously. Its accuracy tops out around 90%, which means it's also still wrong a meaningful share of the time.
A Lancet Digital Health scoping review found the field's fairness metrics fragmented and rarely clinically validated. A second review found that most studies don't measure fairness at all.
In DigiSep, adding metagenomic sequencing to standard cultures did not improve the main 28-day outcome, though ventilation time and shock resolution were shorter in exploratory analyses.
PRoMPT BOLUS, a 9041-child trial across 47 emergency departments, found kidney-injury events at 30 days in 3.4% on balanced fluid and 3.0% on saline (P=0.85) — no meaningful difference.
Vibrio vulnificus wound infections rose eightfold along the Eastern US between 1988 and 2018, and a 2026 model projects recreational-water infection risk climbing up to a thousandfold by 2100.
A Lancet study across 547,000 adults and 925 infectious diseases finds obesity raises the risk of severe infection across almost every pathogen type. The global estimate rests on modelling, not on the cohorts themselves.
Nearly a million conscripts followed for three decades: obesity carried a 3.1-fold hazard for sepsis, and high cardiorespiratory fitness was associated with a 42% lower risk of dying from bacterial infection.
A new GBD analysis puts sepsis-related deaths at 21.4 million, roughly double the 11.0 million estimated for 2017 — a change driven partly by COVID-19 and partly by a different method.