For how we live.
A matched study compared recreational runners, non-runners and adults with obesity, one triplet at a time. The first two groups were indistinguishable on structure and function. The third was not.
A Lancet review triangulates the evidence linking adiposity to multisystem disease and finds robust trial support in a short list — while an expert panel argues the drugs must be lifelong.
The gap between those two numbers is the whole argument. An individual-patient meta-analysis of 20,827 people found real effects on both comparisons, and found that the choice of sham changed the answer.
The WISeR model starts on 1 January in six states. The contractors running it are paid out of the savings their determinations produce — the design feature doctors keep pointing at.
A small prospective cohort followed 62 reconstructions for a quarter century. The graft type made no difference, and the uninjured comparison group dropped out of sport faster.