For how we live.
PRESC1SE-MI covered 67,624 chest-pain presentations at 19 hospitals. The one-hour troponin pathway matched the three-hour one on safety, and median length of stay was identical: 309 minutes.
STAREE randomised 9,971 Australians aged 70 and over to atorvastatin or placebo. Cardiovascular events fell by 30%. Death, dementia and persistent disability, taken together, did not move.
SWITCH-SWEDEHEART randomised regions rather than patients. Over 17,095 people, a default prasugrel policy did not lower ischaemic events against ticagrelor, but major bleeding was lower.
PREMIUM tested prasugrel alone against aspirin plus prasugrel in 2,216 STEMI patients in Japan. Monotherapy failed to show noninferiority, and the confidence interval sat above one.
The Fifth Universal Definition of Myocardial Infarction drops the numbered types, keeps sex-specific troponin thresholds, and proposes ICD-11 codes so the categories can be counted.
ABYSS and SMART-DECISION together cover 6,238 stable patients. Discontinuation cleared both noninferiority margins, though the authors say the primary endpoint's composition limits what it shows.
LIBREXIA-ACS enrolled 14,194 patients before stopping for futility. Milvexian did not reduce events, but intracranial and fatal bleeding were identical to placebo, which is the class's whole premise.
Stanford's SleepFM, published in Nature Medicine in January 2026, is the most consequential sleep paper of the year. Its own limitations section explains why it is not yet a clinical test.
Genetic and trial evidence establishes LDL as causal for atherosclerosis. The same kinds of evidence, applied to HDL, found that raising it does not lower heart attack risk.
Both morning and evening chronotypes showed elevated risk against the middle ground, and the effect nearly doubled in people who also had sleep apnea.
Fine particulate exposure in seven Amazonian capitals was tied to about 5,472 circulatory and 2,621 respiratory deaths over six years. A separate analysis finds cardiac mortality rising with forest loss.
Pooling 11 cohort studies, researchers found a consistent cardiovascular signal in Asian and North American cohorts. European cohorts showed no elevated risk at all, a geographic split the analysis can't explain.
Pooled data across 38 studies found higher coffee intake linked to a higher risk of heart attack — but a lower risk of stroke and irregular heartbeat, with a separate benefit for people with high blood pressure.
In 2,286 patients with sleep apnea undergoing major surgery, a measure of how deeply and how long oxygen fell — not the apnea-hypopnea index — tracked 30-day cardiovascular events and death.
Cedars-Sinai counted a 118% rise in general-illness visits and a 46% rise in heart attack visits over the 90 days after the fires started. Abnormal blood results more than doubled.
An individual-patient meta-analysis of 17,801 patients found a hazard ratio of 0.97 for death, reinfarction or heart failure — a result precise enough to make the question look settled.