For how we live.
In 2.5 million Swedish births followed to adulthood, mothers' early-pregnancy obesity was linked to a stepwise rise in offspring cardiovascular disease, though sibling analyses temper the size.
In 7,530 people from two long-running cohorts, central sleep apnea with high oxygen overshoot carried elevated cardiovascular risk. The same apnea with low overshoot did not.
A first-in-human trial of Kylo-11 reports 97% reduction at 48 weeks after a single dose. A lepodisiran analysis reports near-total clearance of the oxidised phospholipids Lp(a) carries.
The ESC released updated heart failure guidance plus first-ever guidelines on cardiac rehabilitation and on cardiovascular disease with chronic kidney disease. All three sit behind a paywall.
STAREE randomised 9,971 Australians aged 70 and over to atorvastatin or placebo. Cardiovascular events fell by 30%. Death, dementia and persistent disability, taken together, did not move.
WHO and ILO estimate about 17% of workers face hazardous noise. Their review of whether it causes heart disease found only low-certainty signals — one for heart-attack incidence, little for stroke or blood pressure.
Leisure exercise reliably protects the heart. Physical activity done for a living shows mixed or even adverse associations — and some meta-analyses find higher mortality in men with the most physically demanding jobs.
A 1.5-million-person records study reports lower mortality with GLP-1 drugs than with SGLT2 inhibitors, and the largest absolute gains in people with serious mental illness. The design cannot prove it.
PBAC recommended subsidized listing in November 2025 for adults with obesity and a history of heart attack or stroke. Price negotiations with Novo Nordisk had not concluded.
The national framework tracking First Nations health finds real progress on smoking, education and specific diseases, alongside no movement on infant mortality and worsening suicide.
An umbrella review of the meta-analyses puts the association at RR 1.45. The AUA's guideline treats ED as a risk marker, and classes shockwave, stem cell and PRP therapy as investigational.
A study of 9,248 US women published in May 2026 found perimenopausal women twice as likely to fall into the lowest cardiovascular health band. The design cannot show that the decline happens within individuals.
A sibling-controlled cohort of 1.1 million men, a genetic analysis of 712 traits and a UK Biobank study of fitness change converge — and they agree on where the exception is.
Across 89,573 accelerometer-monitored adults and 678 conditions, no disease showed a significant difference between activity concentrated in one or two days and activity spread through the week.
Three 2025 reviews of the same drugs reach three answers: a matched cohort finds less cardiovascular disease on biologics, a network meta-analysis flags one drug as raising events, and 43 trials find nothing.
Across 107 cohort studies and 4.8 million people, the protective effect of moderate drinking disappeared once the comparison group stopped including people who had quit because they were ill.
A national study built for Australia's first Climate Risk Assessment separates the two exposures across ED, inpatient, GP and prescription data. They do not act on the health system the same way.
A harmonised meta-analysis of more than a million people found the association between sitting time and death disappeared in the most active quarter. In the least active, it did not disappear at all.
More than 2,700 people died in England and Wales during the May and June heatwaves. An attribution study assigns roughly 42% of those deaths to warming.
In 390,124 US adults followed up to 27 years, daily multivitamin use showed no mortality benefit. Randomised trials within COSMOS found a real but modest effect on memory, and none on physical function.
A dose-response meta-analysis of 94 cohorts and more than 30 million people found the steepest part of the curve sits between zero and the recommended weekly dose, with small and uncertain gains above double it.
A meta-analysis of 44 cohorts covering 1,864,274 people found the risk signal attached to naps of 30 minutes or more. Below that threshold, no significant risk appeared.
Pooled biomarker data from 30 studies in 13 countries link higher linoleic acid to lower cardiovascular risk. The randomised evidence, 19 trials and 6,461 people, is null and rated low quality.
A pooled analysis of 1.72 million people found no link between an egg a day and cardiovascular disease. A pooled analysis of six US cohorts found one. A randomised trial in 140 high-risk adults found neither.
A 2025 meta-analysis of 57 studies found the mortality curve bending at about 7,000 steps a day. The 10,000 figure traces to the trade name of a Japanese step counter sold in 1965.
A registry study spanning 4.9 million people separates where the most deaths occur from where the inequality is largest. Heart disease and lung disease give different answers.
A first consolidated audit of PBS and PHARMAC cardiovascular listings from 2023 to 2025 finds a widening access gap between two neighbouring countries with similar disease burdens.
Lipfendra cut LDL cholesterol by more than half in two trials. Its significance is less the number than the format: a once-daily tablet where every prior PCSK9 inhibitor required a needle.
Maricopa County runs some of the most detailed heat mortality surveillance in the US. A distributed lag model applied to the same five years put the toll far higher — and the gap is the method, not a scandal.
A Global Burden of Disease comparison puts the 2023 US maternal mortality rate at 33.8 per 100,000 live births, alongside cardio-kidney-metabolic risk burdens several times those of other high-income countries.
Three cohorts, 147,374 people, 30 years and 35,798 deaths. The dose-response curve flattened above 120 minutes per week, and the cancer signal appeared at the low end, not the high end.
The first large-scale policy evaluation of medically tailored meals covers 1,866 recipients across 11 health systems. It is quasi-experimental, not randomised — and that is the finding's main limit.
The ESC Atlas reports 68 million disability-adjusted life years and more than three million cardiovascular deaths a year, with middle-income countries carrying roughly double the mortality of high-income ones.
Stroke is the world's second-leading cause of death and third-leading cause of disability. The new resolution asks countries to build stroke-ready emergency systems, not just treat risk factors.
A meta-analysis spanning two decades of research found extreme cold carried a higher relative risk of death than extreme heat or heatwaves — even as warming shifts public attention toward summer temperatures.
A rapid attribution study finds human-caused warming made this month's record Southwest heat wave far more likely, and doctors warn the early timing caught people unacclimatized.
A wavier jet stream delivered severe cold to three continents in a month that was 1.47°C above pre-industrial globally. Two new studies quantify what cold still does to mortality.
A UK Biobank analysis finds high step counts do not offset short sleep. A US cohort finds one-minute bursts matter. And in older adults, most step-count differences vanish after adjusting for age and sex.
A January study forecasts particulate pollution across six Gulf states and reports Qatar highest at 87.90 µg/m³. The modelling is careful; the input data is annual, national and thirty-one points long.
The 2025–2030 edition was released January 7. It is the first to name highly processed foods, and the first whose saturated-fat arithmetic does not obviously close.
A December survey found getting stronger is the leading 2026 health goal. The best meta-analysis of muscle-strengthening and mortality finds a benefit that plateaus at around 30 to 60 minutes a week.
FDA cleared oral semaglutide 25 mg on 22 December for chronic weight management and cardiovascular risk reduction. Its self-pay price, not its efficacy, is what may distinguish it.
A UK Biobank analysis of 96,365 people found a dose-response relationship between lifetime night-shift exposure and cardiovascular-kidney-metabolic disease — amplified in those who also slept short.
Emergency restrictions came into force on 13 December when the index passed 450. The more telling number is how many days the city has now spent in a category that was meant to be exceptional.
Berkeley researchers followed older Californians for a decade. Cumulative smoke exposure predicted death better than the number of smoke days did — which is not how air quality is usually reported.
The 2025 Lancet Countdown Latin America report tracks 41 indicators across 17 countries. Heat-related deaths are up 103%, and fewer than half the region's governments have finished a vulnerability assessment.
PISCES randomised 1,228 haemodialysis patients in Canada and Australia. The headline hazard ratio of 0.57 counts every event, not just the first — and that choice explains part of the gap.
Carriers of loss-of-function MC4R mutations had lower LDL and triglycerides than UK Biobank controls of similar adiposity, and lower cardiovascular risk. The brain sets body weight and lipids separately.
In 24,223 Swedish workers followed to 2018, insomnia and long sleep raised cardiovascular risk only when accompanied by daytime impairment — and rising sleep duration preceded disease.
A 50-year attribution study separates two trends that usually get modelled as one: rising temperatures and a population that has become less likely to die in them.
Deaths during combined heat and ozone days in Hong Kong, preterm births projected across Chinese cities to 2100, and a seasonal flip in Japan's ambulance demand from winter to summer.