What is insulin resistance, and what are the signs?
Insulin resistance usually causes no symptoms you can feel, which is why it is found through blood tests rather than how you seem. The visible clues are subtle — and it rarely travels alone.
Skin tags: what causes them, whether they signal anything, and can you remove them
These soft flaps are harmless. Their real interest is metabolic — one study tied them to diabetes with an odds ratio of 1.89 — but a 2026 cohort found no link to prediabetes. Removal is cosmetic, not a home job.
Can you reverse prediabetes? What the landmark prevention trial actually showed
Prediabetes is a high-risk state, not a diagnosis of diabetes. In the trial that defined the field, lifestyle change cut progression by 58 percent — and returning to normal glucose carried a benefit of its own.
Removing one mitochondrial protein protected mice from diet-induced obesity
Mice lacking the chaperone GRPEL2 stayed leaner on a high-fat diet and kept better insulin sensitivity — an early mechanistic finding, not a treatment, and so far only in mice.
Weekend lie-ins did not undo a week of short nights in two laboratory studies
In-lab trials that restricted sleep on weekdays and allowed recovery at the weekend found insulin sensitivity and glucose tolerance still worsened. Population surveys point the other way, and the designs explain why.