For how we live.
The 2023 global guideline puts lifestyle first for everyone, letrozole first for fertility, and the pill for cycles and excess hair — while rating much of its own evidence low to moderate quality.
In two large clinics, the live birth rate per woman who returned to use her eggs was around 39-50% under 35 or 38, but far lower for older women — and most women who froze never came back to use them.
In modern couples timing intercourse, an estimated 18% of women aged 35-39 failed to conceive within a year — not one in three. The most alarming figures come from models, not from watching real couples try.
Using genetic variants as instruments, researchers found exercise and wellbeing lowered risk of PCOS, endometriosis and menstrual disorders, while screen time and mood swings raised it.
An 876-participant double-blind trial across 24 Chinese fertility centres nearly doubled serum 25-OHD in women with PCOS. Live births were 52.0% against 50.2% on placebo.