For how we live.
In midlife women the usual cause is the menopause transition, where hot flushes and night sweats last a median of seven years. In older adults they are common, mostly benign, and rarely a mortality signal.
Cognitive behavioural therapy is one of the few non-hormone options the North American Menopause Society backs at its top evidence level. What it changes is how much flushes bother you, not the thermostat.
A landmark US cohort found frequent hot flushes lasted a median of 7.4 years, and 4.5 years after the last period. When they start earlier in the transition, they tend to last far longer.
An industry-standard indirect comparison of fezolinetant and elinzanetant found comparable reductions in vasomotor symptoms. Elinzanetant improved sleep disturbance more, without a difference in overall quality of life.
Lynkuet is the second neurokinin-targeted drug cleared in the US for vasomotor symptoms. The trials found no hepatotoxic effects; FDA still asked for three years of enhanced liver-injury reporting.