What is a silent heart attack, and how often does one go unnoticed?
Some heart attacks leave scar on an ECG or MRI but were never felt as one. In a long US cohort they made up more than 45% of heart attacks — and they still shortened survival.
More women than men have a heart attack without the classic chest pain
The crushing chest pressure is real and common. But in a registry of more than a million patients, 42% of women arrived without chest pain, against 31% of men — and the gap was widest in the young.
Vigorous exercise tracked with less fragmented sleep in women with apnea, not men
Women who reported vigorous physical activity had a lower arousal index, less time awake after falling asleep, and more total sleep time. The same association didn't hold for arousal index in men.
Women enrolled unevenly in trials, then dosed as if the difference didn't exist
A systematic review of 27 studies finds women reach higher drug concentrations at the same psychotropic dose. A separate review of 103 atrial fibrillation trials finds 43% under-enrolled women against disease prevalence.
Women improved more than men on esketamine — and more on placebo too
A pooled analysis of five trials in treatment-resistant depression found sex differences in response. The largest ones appeared in both arms, which points at something other than the drug.
Autism's four-to-one sex ratio may be an artefact of when girls get diagnosed
A Swedish birth cohort of 2.76 million people found the cumulative male-to-female ratio for autism incidence had fallen to 1.2 by age 20 — and projects parity by 2024.