For how we live.
In 415,000 New Jersey births, infants of mothers who screened positive for depression died before age one at more than three times the rate, an association steady across race, income and preterm birth.
Screening 2,904 proteins in early pregnancy, researchers found low maternal isthmin-2 was the strongest signal for later preeclampsia or fetal growth restriction, validated in two cohorts.
Across 16,893 high school athletes screened over 15 years, 0.36% had T-wave inversions. Four were later found to have hypertrophic cardiomyopathy, a leading cause of sudden cardiac death in the young.
Applied to 411,000 UK Biobank adults, the Edmonton staging system and the Lancet Commission's clinical-obesity model classified severe disease alike but diverged on who counts as early-stage.
13% of women met criteria for insomnia disorder six weeks after delivery, and only two had been evaluated. In a separate cohort, restless legs in pregnancy tripled the risk of perinatal depression.
The REACT study imaged people aged 18 to 70 with no known cardiovascular disease. Atherosclerosis was already present in some people in their twenties, and it was usually in the legs, not the heart.
Dense tissue raises breast-cancer risk and hides cancers on a mammogram. US facilities must now tell patients — but the evidence on what to do next is a real trade-off: more cancers found, more false alarms.
A facility-based study of 5,053 infants finds undernutrition begins earlier than the age group nutrition programmes usually screen — and that weight-for-age caught far more of it than arm-circumference tape.
US guidelines recommend routine chlamydia and gonorrhea screening for sexually active women under 25 and older women at higher risk. Self-collected swabs match clinician-collected ones closely.
In 152 adults tested against two nights of polysomnography, the Galaxy Watch reached an AUROC of 0.94 for moderate-to-severe sleep apnea — with 66.7% specificity at the setting it ships with.
The country's blood-spot programme has run since 2003 and reaches nearly every baby. A pilot adds genomic sequencing — where a study of Qatari genomes suggests the biggest gains lie.
A mandatory citywide programme sequenced 782 genes in 1,000 prospective couples. The at-risk rate was double that of a comparable Australian study, and most flagged couples still chose to marry.
Hepatitis C is usually silent for years and is the reason for much chronic liver disease. A short course of antiviral pills cures more than 95% of cases, which is what changed the screening advice.
A Cochrane review of 251,891 participants found no effect on total, cancer or cardiovascular mortality, at high certainty for the first two. The finding is about check-ups, not about all screening.
Only three of the 15 studies pooled in a Chilean meta-analysis used sleep testing at all. A Lima clinic analysis shows why that shortcut matters.
WHO data put the normal window for walking alone at 8.2 to 17.6 months. The 2022 CDC checklists moved to the age by which 75% of children reach a milestone — to flag real delay, not redefine normal.
The approved tests are for patients already showing cognitive decline. Used on the worried well, a positive result mostly signals a risk that may never become disease — and no treatment follows from it.
In 555,904 matched adults, screening endoscopy cut gastric cancer mortality in the 50s and 60s. Past 80, or with heavy comorbidity, the association reversed.
A comparative survey finds four European countries still rely on opportunistic screening, and that where family doctors are most involved, participation tends to be lower — not higher.
The best-validated sleep apnea screener works by being wrong in a specific direction. A 47-study meta-analysis of 26,547 people shows what a questionnaire can and cannot conclude about you.
A Qatar Biobank analysis derived local cut-points and found WHO's standard numbers misclassified more than half of men and nearly half of women in the sample.
A secondary analysis of the VITAL-AF trial reports a screening benefit only in the top risk decile — with a confidence interval whose lower bound sits at 0.01.
The LiverScreen project ran transient elastography across nine countries, then sent everyone who screened positive to a hepatologist. The gap between the two numbers is the interesting part.
Fifty-five per cent of surveyed cricketers over 70 reported a basal cell carcinoma. A 29% response rate and self-reported diagnoses mean the number cannot be read as a rate — which is the finding.
Pooling 94 cohort studies, grip strength tracked with later dementia, depression and disability. The authors rate their own confidence in the numbers as limited to moderate.
SCREESCO randomised Swedish 60-year-olds to colonoscopy, stool testing, or nothing. After a median 4.8 years, overall cancer incidence barely moved; the stage distribution did.
WISDOM randomised 28,372 women to annual mammography or a risk-tailored schedule. The risk-based arm met its non-inferiority mark for advanced cancers — with caveats about who enrolled.
IARC and WHO put five modules on screening and precancer management online. The 90-70-90 targets they support depend on health workers who can act on a positive test.
Fourteen studies covering 265 elite athletes used six different methods to identify relative energy deficiency. The spread in the answers is mostly a spread in the definitions.
EyeFM was tested as an assistant to 16 ophthalmologists screening 668 high-risk patients in China. Patients in the AI arm also followed referral advice more often.
EchoNext scored 77.3% accuracy on a 150-ECG set where 13 cardiologists averaged 64.0%. Its authors released the model weights and a 100,000-ECG labelled dataset alongside the paper.