For how we live.
Linking exome data to electronic medical records solved 15% of unexplained hearing-loss cases and flagged new candidate genes — while showing what the records could not supply.
The country's blood-spot programme has run since 2003 and reaches nearly every baby. A pilot adds genomic sequencing — where a study of Qatari genomes suggests the biggest gains lie.
A mandatory citywide programme sequenced 782 genes in 1,000 prospective couples. The at-risk rate was double that of a comparable Australian study, and most flagged couples still chose to marry.
A meta-analysis of 27 randomised trials found that disclosing a polygenic risk score did not meaningfully shift diet, screening uptake, medication use, anxiety or cholesterol.
Two Nature papers describe the Taiwan Precision Medicine Initiative and the risk scores built from it. The genetic effects identified explained up to 10.3% of health variation in the cohort.