For how we live.
In 108 people with Parkinson's, diffusion MRI found that damage to cholinergic pathways running from a deep-brain nucleus tracked worse cognition — and was most marked in those with dementia.
Two 2026 trials point the same direction: the hardware in depression treatment is mature, and the remaining gains are in precision and in what the treatment costs the patient's memory.
747 postmenopausal women were tested; 182 were scanned. Gray matter volume partially mediated the link between menopause age and cognition — in a cross-sectional design that cannot establish direction.
In 85 people with mild cognitive impairment, transient beta-band events recorded at rest differed years before diagnosis. The sample is small and the finding has not been replicated.
Pooling 31 studies of 556 patients, cortical 5-HT2A binding was lower in unmedicated depression than in controls. The post-mortem studies mostly found nothing, and the tracers used shape the result.