For how we live.
In 947 Chinese children followed for ten years, those with insulin resistance despite normal blood sugar had a 4.3-fold higher risk of later dysglycaemia, and six amino acids helped predict who would develop it.
No. Sweat is how the body sheds heat, not fat. The weight lost in a hot workout or a sauna is water, and it comes back the moment you rehydrate.
Barely, and some carry real risk. Caffeine has a small, measurable effect; the other headline 'thermogenic' ingredients mostly don't, and high-dose green tea extract has caused liver injury.
Losing weight lowers resting metabolism and keeps it low — Biggest Loser contestants ran hundreds of calories below baseline six years on. But that brake slows loss; it does not store fat.
Exercising before breakfast shifts which fuel your body uses during the session, but pooled trials find no meaningful edge for weight or body-fat loss over the same workout done fed.
Six years after 'The Biggest Loser', contestants had regained most of the weight — and their resting metabolism was still running 500 calories a day slower than expected. The diet triggers a defence that outlasts it.
An unplanned cheat day can erase a week's calorie deficit and has no trial support. Structured diet breaks are different — one trial found they improved weight loss, though another found no body-composition edge.
A kilogram of muscle burns about 13 calories a day at rest — far less than the fitness-marketing figure implies. But resistance training does nudge resting metabolism up, by roughly 96 calories a day in a meta-analysis.
A large study of energy use across the lifespan found it holds steady from age 20 to 60, once body size is accounted for. The midlife metabolic slump is mostly a myth; the decline comes later.
Mice lacking the chaperone GRPEL2 stayed leaner on a high-fat diet and kept better insulin sensitivity — an early mechanistic finding, not a treatment, and so far only in mice.
Orforglipron removes the injection from weight-loss medicine — a real change for people who refused one. Supply, cost, and coverage are the harder problems it does not solve.
University of Florida researchers identify excess glycan production as a driver of Alzheimer's pathology, and find oral glucosamine worsened cognition in mice and tracked with faster decline.
The trial's own primary outcome — inflammation — was flat. What the new analysis adds is a molecular account of why the fat loss did not translate into the benefits fasting is sold on.