Metformin's case as an anti-ageing drug now rests on three null results
Twenty-one years of cancer follow-up, multimorbidity data to 2021, and a randomised trial in frail older adults. In each, metformin did not beat placebo. Lifestyle change did.
Your biological age test returns a number. Here is what it can support.
Consumer clocks report an age, an age gap or a pace of ageing. Expert panels agree no single biomarker is sufficient — and clocks have failed to move when an intervention demonstrably worked.
A philanthropist is paying for the rapamycin trial no drug company would fund
A $12 million gift will test whether low-dose rapamycin changes the transition to frailty in adults over 65 — the first study of the drug designed around an outcome rather than a biomarker.
PEARL rapamycin trial results: safe over a year, primary endpoint unmoved
The longest human trial of low-dose rapamycin for healthy ageing found no change in visceral fat, its own primary outcome. The positive findings it is quoted for rest on eight women.
Fewer than a dozen trials: the whole human evidence base for longevity rapamycin
A 2025 review walked through every study of low-dose rapamycin in healthy adults. The immune findings are real, the outcome data do not exist, and the review's own worked example does not add up.
Senolytics: two randomised trials, and no confirmed clinical benefit yet
A phase 2 trial of dasatinib plus quercetin missed its bone endpoint. A senolytic injected into the eye produced a 5.6-letter vision gain whose confidence interval crosses zero.
Taurine does not fall with age after all, a second Science paper reports
In 2023 declining taurine was proposed as a driver of ageing. Two years later the same journal published human, monkey and mouse data in which taurine rose or stayed flat.
Five of fourteen consensus aging biomarkers predicted death in a 1,083-person cohort
Longevity trials want a measurement that moves in months instead of decades. A Berlin study ranked the candidates, and a four-week diet trial showed what a clock does when nothing much happens.