For how we live.
A double-blind Danish trial gave the drug or placebo during resuscitation at 21 hospitals. Restored circulation occurred in 39% versus 37% — no meaningful difference — and bicarbonate raised blood alkalosis and sodium.
The PROPOSITIS trial put babies on high-flow oxygen face-down or on their backs. Escalation of care was 15% versus 21% — a difference that did not reach significance, and the authors call the study inconclusive.
In GASTRIC-PICU, 4,700 ventilated children were randomised to routine gastric residual checks or none. Dropping the checks was non-inferior for survival and ventilator-free days, and improved nutrition.
VICTORY randomised 238 adults with severe burns to intravenous vitamin C or placebo. It was stopped early: 28-day mortality was 15.0% versus 7.6%, and the trial crossed a prespecified harm threshold.
Across 41 hospitals in 19 Asian countries, ACORN-HAI found 73.7% of severe bloodstream and ventilator infections were drug-resistant, and 37.7% of those patients died within 28 days.
Sepsis is the body's own response to an infection turning against its organs. It kills an estimated 11 million people a year, and the evidence keeps pointing to how fast it is caught and treated.
PRoMPT BOLUS, a 9041-child trial across 47 emergency departments, found kidney-injury events at 30 days in 3.4% on balanced fluid and 3.0% on saline (P=0.85) — no meaningful difference.
A new GBD analysis puts sepsis-related deaths at 21.4 million, roughly double the 11.0 million estimated for 2017 — a change driven partly by COVID-19 and partly by a different method.