For how we live.
Teva's subcutaneous depot is built to avoid the post-injection sedation that hobbled the first olanzapine shot. It cleared the FDA on 8 October; in the phase 3 SOLARIS trial it beat placebo on symptoms at eight weeks.
A matched cohort of 173,910 people with dementia in England tied the drugs to raised risks of pneumonia, stroke, clots, heart attack, fracture and kidney injury — highest just after starting.
A systematic review of 27 studies finds women reach higher drug concentrations at the same psychotropic dose. A separate review of 103 atrial fibrillation trials finds 43% under-enrolled women against disease prevalence.
A network meta-analysis of 41,084 surgical patients over 60 ranked 52 drug interventions. Dexmedetomidine held up after high-risk trials were excluded; almost nothing changed length of stay or mortality.
A within-individual analysis of 505,474 people in Finland and Sweden found lower psychiatric hospitalisation on clozapine in every disorder studied except borderline personality disorder, with no excess mortality signal.