For how we live.
Acne is not caused by dirt or bad washing, and it does respond to treatment. Guidelines strongly back benzoyl peroxide and topical retinoids first, with oral isotretinoin reserved for severe or scarring acne.
Users were slightly less likely than non-users to attempt suicide in the two to four years after treatment. The FDA's 2005 boxed warning stands, and the analysis cannot explain the direction of the finding.
Cochrane pooled 106 randomised trials in 13,631 people; a phenotype-led update reached 152 studies. The best evidence is feature-by-feature — brimonidine for redness, ivermectin and azelaic acid for pustules.