FDA clears Breztri for asthma and adds a lower-warming propellant
Approved on 8 October, the triple inhaler gains a maintenance asthma use for ages 12 and up. In two trials it beat a two-drug inhaler on lung function, but not on severe flare-ups.
Adding budesonide to surfactant did not improve lung outcomes in extremely preterm babies
The PLUSS trial put a steroid directly into the lungs of 1,059 infants born before 28 weeks. Survival free of chronic lung disease barely differed from surfactant alone.
Croup: why one dose of steroid is the standard treatment
Croup gives young children a barking cough and noisy breathing. It is usually mild and self-limiting, and a single dose of oral steroid shortens it — with a low dose working about as well as a high one.
Triple inhaler therapy cuts COPD flare-ups more than two-drug inhalers
Two large trials, ETHOS and IMPACT, found adding an inhaled steroid to a two-bronchodilator inhaler lowered exacerbation rates in COPD — at the cost of more pneumonia.
Childhood asthma: what the evidence says on diagnosis and inhaled steroids
Guidelines now ask for an objective test before an asthma label is fixed to a child, and inhaled steroids remain the mainstay of control. Their benefit is real; so is a small, mostly temporary effect on growth.
Four trials ended the case for treating mild asthma with a reliever inhaler alone
Adding an inhaled steroid to the as-needed inhaler roughly halved severe attacks against a short-acting reliever, at a fraction of the daily steroid exposure that maintenance therapy delivers.