What the letter grade on a cancer-screening recommendation actually means
A, B, C, D and I are not school marks. They encode how strong the evidence is, whether to screen at all — and in the US, whether insurance has to pay for it.
Why there is no routine screening for pancreatic cancer, and what raises the risk
The disease is lethal largely because it is found late. That is also why guidelines recommend against screening the general public — the evidence says it would do more harm than good.
What a cancer 'stage' actually means, and what it does not
Stage describes how far a cancer has spread at diagnosis. It is not the same as grade, it is set once, and it drives both prognosis and treatment more than almost any other number.