For how we live.
A deep-learning model reads the pancreas on non-contrast CT taken for other reasons. It reached very high accuracy in large tests — none of them a prospective screening trial.
A, B, C, D and I are not school marks. They encode how strong the evidence is, whether to screen at all — and in the US, whether insurance has to pay for it.
The disease is lethal largely because it is found late. That is also why guidelines recommend against screening the general public — the evidence says it would do more harm than good.
Stage describes how far a cancer has spread at diagnosis. It is not the same as grade, it is set once, and it drives both prognosis and treatment more than almost any other number.
Bizengri now covers NRG1-fusion cholangiocarcinoma, a mutation found in a fraction of a fraction of cases. The evidence is 19 patients, of whom about a third responded.