WELL CURVEA meta-analysis of 30 randomised trials found fibre supplements work in IBS, with the benefit concentrated in psyllium. Wheat bran was the most-studied type and did not carry the effect.
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ANALYSISA network meta-analysis found route of delivery decides everything, and that autologous transplant ranked below placebo. In IBS, 13 trials produced very low certainty of any effect.
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ANALYSISTwelve studies in 1,158 IBS patients found gut-directed hypnotherapy improved symptoms, with the firmest results in high-volume and group delivery. The microbiome route is weaker.
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WHAT THE STUDY ACTUALLY SAYSTwo double-blind crossover studies in people who had put themselves on gluten-free diets failed to reproduce a gluten effect. One found a different wheat carbohydrate did it instead.
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EXPLAINERBloating and visible distension are different problems with different mechanisms. The 2025 ESNM/UEG consensus found visceral hypersensitivity, not gas volume, doing most of the work.
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ANALYSISA network meta-analysis of 13 randomised trials put the diet ahead of every alternative for IBS symptoms. Its authors note the trials skipped reintroduction and personalisation entirely.
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EXPLAINERThe American College of Gastroenterology suggests a positive diagnostic strategy over a diagnosis of exclusion, with two blood and stool tests doing most of the ruling-out that is actually warranted.
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ANALYSISThe trial was designed to test non-inferiority against traditional dietary advice. It found superiority instead, with 62% versus 42% achieving a clinical response over six weeks.
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