For how we live.
A network meta-analysis of 118 trials and 31,195 men found every oral PDE5 inhibitor beat placebo, with tadalafil ranked most effective. Guidelines make the tablets, after a health check, the first-line choice.
A study of 3,932 athletes found cyclists had no worse erectile or urinary function than swimmers and runners. But heavy saddle time is tied to genital numbness, and men logging 5+ hours a week showed lower sperm counts.
The only FDA-approved drug for the penile-curvature disorder straightens the average man's bend only modestly more than placebo. Surgery is more definitive, and most oral remedies are unsupported.
An umbrella review of the meta-analyses puts the association at RR 1.45. The AUA's guideline treats ED as a risk marker, and classes shockwave, stem cell and PRP therapy as investigational.