For how we live.
More than 410,000 probable cases so far in 2026, against 1.45 million for all of 2025. One state, Minas Gerais, accounts for roughly a sixth of the national case total on its own.
Two 2026 papers describe the same shift: rural incidence now exceeds urban in some years, the peak has slid to October and November, and one in six hospitalised patients progressed to severe disease.
A CDC surveillance summary puts 2024 at 359% above the 2010–2023 annual average. The 2.8% that were locally acquired are the part that changes what mosquito control has to plan for.
A cluster-randomised trial across 15 population clusters found mosquito abundance collapsed in intervention areas and protective efficacy of 71–72% against symptomatic dengue.
In a controlled human infection trial, high-dose mosnodenvir suppressed DENV-3 far below placebo. Resistance-associated changes appeared in every sequenced recipient and none of the placebo group.
The 2025 Lancet Countdown Latin America report tracks 41 indicators across 17 countries. Heat-related deaths are up 103%, and fewer than half the region's governments have finished a vulnerability assessment.