Borderline Personality Disorder

3 articles published between November 4, 2025 and April 16, 2026.

THE DRUG DOCKET

Psilocybin eased depression but not BPD symptoms in a nine-person pilot

The open-label pilot tested a specific worry in psychedelic research — that borderline personality disorder blunts response to psilocybin for depression. In this small sample, it didn't.

3 min read

WHAT THE STUDY ACTUALLY SAYS

Personality disorder is common and shortens life — and is absent from the GBD

A meta-regression across 28 countries put pooled prevalence near 4-5% and standardised mortality ratios between 1.8 and 4.7, in a condition the Global Burden of Disease study does not count.

3 min read

WHAT THE STUDY ACTUALLY SAYS

Clozapine outperformed other antipsychotics across six diagnoses — but not in BPD

A within-individual analysis of 505,474 people in Finland and Sweden found lower psychiatric hospitalisation on clozapine in every disorder studied except borderline personality disorder, with no excess mortality signal.

3 min read

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Borderline Personality Disorder

Psilocybin eased depression but not BPD symptoms in a nine-person pilot

Personality disorder is common and shortens life — and is absent from the GBD

Clozapine outperformed other antipsychotics across six diagnoses — but not in BPD

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