For how we live.
The signalling that builds muscle in youth appears to speed ageing and cancer. People with lifelong GH deficiency avoid both — and GH given to healthy older adults raises harms without extending life.
Oral paltusotine kept median IGF-I near the normal ceiling through week 207 in an open-label extension, but only 20 of 43 patients remained by then and the study had no comparison group.
Palsonify is cleared for adults whose acromegaly did not respond adequately to surgery. In the phase 3 switching trial, 83.3% on the pill kept biochemical control versus 3.6% on placebo.