https://www.healthnewspapers.com/science Trials, journals, oncology, genomics, and the long work of proving things. en-us https://www.healthnewspapers.com/science/prenatal-water-fluoride-child-behaviour-echo https://www.healthnewspapers.com/science/prenatal-water-fluoride-child-behaviour-echo In 5,520 children across 34 states, prenatal exposure to regulated public-water fluoride showed no association with emotional or behavioural problems overall — with one caveat in a secondary model. Thu, 03 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/paradigm-azacitidine-venetoclax-aml-induction https://www.healthnewspapers.com/science/paradigm-azacitidine-venetoclax-aml-induction In the 172-patient PARADIGM trial, azacitidine plus venetoclax more than doubled median event-free survival versus induction chemotherapy — but it was a phase 2 study not powered for overall survival. Thu, 03 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/gildeuretinol-stargardt-tease-1-trial https://www.healthnewspapers.com/science/gildeuretinol-stargardt-tease-1-trial Stargardt disease, the most common inherited macular dystrophy, has no approved treatment. In the 50-patient TEASE-1 trial, gildeuretinol slowed atrophic lesion growth by a fraction of a millimetre a year. Thu, 03 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/daraxonrasib-ras-mutant-nsclc-early-trial https://www.healthnewspapers.com/science/daraxonrasib-ras-mutant-nsclc-early-trial In an early-phase trial of 136 previously treated patients, daraxonrasib produced responses in 31–37% depending on dose — but 54% had a serious side effect, and this is a phase 1–2 study. Thu, 03 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/nsabp-b59-atezolizumab-triple-negative-breast-cancer https://www.healthnewspapers.com/science/nsabp-b59-atezolizumab-triple-negative-breast-cancer In the NSABP B-59 trial, adding the immunotherapy to neoadjuvant chemotherapy did not significantly improve event-free survival, while immune-related side effects more than doubled. Wed, 02 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/fluconazole-mycobiome-inflammatory-bowel-disease https://www.healthnewspapers.com/science/fluconazole-mycobiome-inflammatory-bowel-disease In 53 patients, oral fluconazole — but not a mouth-only antifungal — cut gut Candida and coincided with improved disease activity. The study was observational, brief and unblinded. Wed, 02 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/ervebo-health-worker-vaccination-bundibugyo https://www.healthnewspapers.com/science/ervebo-health-worker-vaccination-bundibugyo Ervebo was licensed against Zaire ebolavirus. WHO says it is not known whether it protects against Bundibugyo virus in humans — which is why a trial is running alongside the wider rollout. Tue, 01 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/disease-modifying-osteoarthritis-drugs https://www.healthnewspapers.com/science/disease-modifying-osteoarthritis-drugs Lorecivivint improved pain modestly and changed nothing structural. Sprifermin grew cartilage and the effect made no difference by year five. Both illustrate the gap between a biomarker and a benefit. Tue, 01 Sep 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/silent-atherosclerosis-prevalence-react https://www.healthnewspapers.com/science/silent-atherosclerosis-prevalence-react The REACT study imaged people aged 18 to 70 with no known cardiovascular disease. Atherosclerosis was already present in some people in their twenties, and it was usually in the legs, not the heart. Mon, 31 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/rsv-vaccine-second-season-durability https://www.healthnewspapers.com/science/rsv-vaccine-second-season-durability Two pragmatic randomised trials and a Medicare nursing home cohort landed in the same week. Together they show real protection against hospitalisation and a durability question nobody has answered. Mon, 31 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/presc1se-mi-rapid-troponin-pathway-emergency-department https://www.healthnewspapers.com/science/presc1se-mi-rapid-troponin-pathway-emergency-department PRESC1SE-MI covered 67,624 chest-pain presentations at 19 hospitals. The one-hour troponin pathway matched the three-hour one on safety, and median length of stay was identical: 309 minutes. Mon, 31 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/pfas-destruction-groundwater-remediation https://www.healthnewspapers.com/science/pfas-destruction-groundwater-remediation Carbon filters and ion exchange concentrate PFAS rather than breaking it down, which turns treated water into a residual-waste problem. A new review puts numbers on what destruction would cost in energy. Mon, 31 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/pcbs-predicted-cardiovascular-risk-china https://www.healthnewspapers.com/science/pcbs-predicted-cardiovascular-risk-china A Chinese cohort found serum PCBs associated with a higher calculated 10-year cardiovascular risk. The longitudinal results did not survive correction for multiple testing, and no events were counted. Mon, 31 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/pain-undertreatment-disparities-evidence https://www.healthnewspapers.com/science/pain-undertreatment-disparities-evidence The beliefs — that Black patients' skin is thicker, their nerve endings less sensitive — predicted lower pain ratings and less accurate treatment recommendations for a Black patient in the same experiment. Mon, 31 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/lipoprotein-a-sirna-kylo-11-lepodisiran https://www.healthnewspapers.com/science/lipoprotein-a-sirna-kylo-11-lepodisiran A first-in-human trial of Kylo-11 reports 97% reduction at 48 weeks after a single dose. A lepodisiran analysis reports near-total clearance of the oxidised phospholipids Lp(a) carries. Mon, 31 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/water-fluoridation-evidence-review https://www.healthnewspapers.com/science/water-fluoridation-evidence-review Cochrane's 2024 review found low-certainty evidence of a small effect since fluoride toothpaste became widespread. The IQ meta-analysis that reopened the argument reported a null below 1.5 mg/L in one key analysis. Sun, 30 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/response-tailored-antibiotics-endocarditis-poet-ii https://www.healthnewspapers.com/science/response-tailored-antibiotics-endocarditis-poet-ii POET II randomised 508 stabilised patients to stop antibiotics or complete the standard course. The safety endpoint met noninferiority; relapse of infection did not go the same way. Sun, 30 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/pvi-sham-af-catheter-ablation-trial https://www.healthnewspapers.com/science/pvi-sham-af-catheter-ablation-trial The first double-blind sham-controlled trial of pulmonary vein isolation found quality of life improved in both arms. Most of the benefit patients feel appears not to come from the ablation. Sun, 30 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/prenatal-chemical-mixtures-signal-and-null https://www.healthnewspapers.com/science/prenatal-chemical-mixtures-signal-and-null One found specific phenanthrene metabolites associated with fetal growth restriction and chased the mechanism. The other tested a 24-metabolite mixture against ADHD in 3,962 children and found nothing. Sun, 30 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/fifth-universal-definition-myocardial-infarction https://www.healthnewspapers.com/science/fifth-universal-definition-myocardial-infarction The Fifth Universal Definition of Myocardial Infarction drops the numbered types, keeps sex-specific troponin thresholds, and proposes ICD-11 codes so the categories can be counted. Sun, 30 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/milvexian-librexia-acs-futility https://www.healthnewspapers.com/science/milvexian-librexia-acs-futility LIBREXIA-ACS enrolled 14,194 patients before stopping for futility. Milvexian did not reduce events, but intracranial and fatal bleeding were identical to placebo, which is the class's whole premise. Sat, 29 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/eplontersen-attr-cm-cardio-ttransform https://www.healthnewspapers.com/science/eplontersen-attr-cm-cardio-ttransform CARDIO-TTRansform randomised 1,432 patients with transthyretin amyloid cardiomyopathy to eplontersen or placebo for 140 weeks. The confidence interval around the primary result crosses one. Sat, 29 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/fmt-beyond-c-difficile-evidence https://www.healthnewspapers.com/science/fmt-beyond-c-difficile-evidence A network meta-analysis found route of delivery decides everything, and that autologous transplant ranked below placebo. In IBS, 13 trials produced very low certainty of any effect. Fri, 28 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/atopic-march-evidence https://www.healthnewspapers.com/science/atopic-march-evidence Two birth cohorts totalling 9,801 children were sorted into eight developmental patterns. The classic progression was one of them, and one of the smallest. Fri, 28 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/arizona-phase-3-rapamycin-frailty-trial https://www.healthnewspapers.com/science/arizona-phase-3-rapamycin-frailty-trial A $12 million gift will test whether low-dose rapamycin changes the transition to frailty in adults over 65 — the first study of the drug designed around an outcome rather than a biomarker. Fri, 28 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/suppressor-trna-lipid-nanoparticle-cystic-fibrosis https://www.healthnewspapers.com/science/suppressor-trna-lipid-nanoparticle-cystic-fibrosis Suppressor tRNAs have been a promising idea for nonsense mutations for years, held back by weak activity and delivery. A Science paper reports one chemical tweak and one redesigned nanoparticle. Thu, 27 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/pearl-rapamycin-trial-results https://www.healthnewspapers.com/science/pearl-rapamycin-trial-results The longest human trial of low-dose rapamycin for healthy ageing found no change in visceral fat, its own primary outcome. The positive findings it is quoted for rest on eight women. Wed, 26 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/gut-brain-axis-what-the-evidence-supports https://www.healthnewspapers.com/science/gut-brain-axis-what-the-evidence-supports Twelve studies in 1,158 IBS patients found gut-directed hypnotherapy improved symptoms, with the firmest results in high-volume and group delivery. The microbiome route is weaker. Wed, 26 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/alopecia-areata-jak-inhibitor-trials https://www.healthnewspapers.com/science/alopecia-areata-jak-inhibitor-trials In two phase 3 trials, 38.8% and 35.9% on baricitinib 4 mg reached near-complete scalp regrowth at 36 weeks against 6.2% and 3.3% on placebo — the first drug class to do this for the condition. Wed, 26 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/public-database-mining-research-integrity https://www.healthnewspapers.com/science/public-database-mining-research-integrity An investigation into the flood of papers mining one public health database found something more awkward than organised fraud: an open marketplace of tools that lets anyone produce a publishable analysis in an afternoon. Tue, 25 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/dubai-premarital-genomic-screening https://www.healthnewspapers.com/science/dubai-premarital-genomic-screening A mandatory citywide programme sequenced 782 genes in 1,000 prospective couples. The at-risk rate was double that of a comparable Australian study, and most flagged couples still chose to marry. Tue, 25 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/leaky-gut-clinical-concept-evidence https://www.healthnewspapers.com/science/leaky-gut-clinical-concept-evidence A review in Gut says no intestinal disease can be cured by normalising barrier function, and that it is unproven whether restoring the barrier improves any clinical outcome at all. Mon, 24 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/zinc-supplementation-sickle-cell-anemia-uganda-trial https://www.healthnewspapers.com/science/zinc-supplementation-sickle-cell-anemia-uganda-trial A 100-child randomized trial in Uganda found a cheap supplement lowered infection rates on top of standard hydroxyurea therapy — though the authors say it needs a bigger trial before it changes practice. Sun, 23 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/child-development-milestones-normal-variation https://www.healthnewspapers.com/science/child-development-milestones-normal-variation WHO data put the normal window for walking alone at 8.2 to 17.6 months. The 2022 CDC checklists moved to the age by which 75% of children reach a milestone — to flag real delay, not redefine normal. Sat, 22 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/alzheimers-blood-tests-asymptomatic-people https://www.healthnewspapers.com/science/alzheimers-blood-tests-asymptomatic-people The approved tests are for patients already showing cognitive decline. Used on the worried well, a positive result mostly signals a risk that may never become disease — and no treatment follows from it. Sat, 22 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/mrna-cancer-vaccine-melanoma https://www.healthnewspapers.com/science/mrna-cancer-vaccine-melanoma Moderna and Merck's personalized vaccine slowed melanoma's return when added to Keytruda. It is the first mRNA cancer vaccine to succeed at scale — and the first real test of a decade-old idea. Fri, 21 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/er-100-partial-reprogramming-first-in-human https://www.healthnewspapers.com/science/er-100-partial-reprogramming-first-in-human Three of the four Yamanaka factors, delivered to one eye and switched on with an antibiotic for eight weeks. The mouse data are striking; the trial is a safety study and will not measure ageing. Fri, 21 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/cgd-mena-registry-recessive-burden https://www.healthnewspapers.com/science/cgd-mena-registry-recessive-burden Chronic granulomatous disease is usually X-linked in Western cohorts. A multicentre Middle East and North Africa registry found the opposite pattern, alongside late diagnosis and a median survival of 8.5 years. Fri, 21 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/vpm1002-versus-bcg-newborn-tuberculosis-trial https://www.healthnewspapers.com/science/vpm1002-versus-bcg-newborn-tuberculosis-trial VPM1002 did not show non-inferiority to BCG for preventing tuberculosis infection in a phase 3 trial across sub-Saharan Africa. Far fewer infections occurred than planned, leaving the comparison unresolved. Wed, 19 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/hygiene-hypothesis-evidence https://www.healthnewspapers.com/science/hygiene-hypothesis-evidence Farm-raised children really are protected from asthma, and the mechanism has been traced to microbial exposure and innate immunity. What has not been shown is that household hygiene caused the allergy epidemic. Tue, 18 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/egfr-creatinine-blood-test-meaning https://www.healthnewspapers.com/science/egfr-creatinine-blood-test-meaning Creatinine is muscle waste your kidneys clear; eGFR is an estimate of filtering capacity built from it. A single reading is a snapshot, not a diagnosis — and the equations have limits worth knowing. Mon, 17 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/hpv-vaccine-cervical-cancer-reduction-evidence https://www.healthnewspapers.com/science/hpv-vaccine-cervical-cancer-reduction-evidence Two national studies settle the question the trials could not: in England, cancer rates fell 87% among those vaccinated at 12-13; in Sweden, the risk was cut by nearly two-thirds. Sat, 15 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/oropouche-brain-organoids-microcephaly-signal https://www.healthnewspapers.com/science/oropouche-brain-organoids-microcephaly-signal A Brazilian laboratory study found both a prototype strain and an emergent reassortant killed neural progenitors and collapsed cortical structure. This is a dish, not a pregnancy. Wed, 12 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/epigenetic-clocks-as-trial-endpoints https://www.healthnewspapers.com/science/epigenetic-clocks-as-trial-endpoints Longevity trials want a measurement that moves in months instead of decades. A Berlin study ranked the candidates, and a four-week diet trial showed what a clock does when nothing much happens. Tue, 11 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/placebo-response-pain-trials https://www.healthnewspapers.com/science/placebo-response-pain-trials Analgesic trials keep failing, and one reason is that the comparison arm keeps improving. Where a trial recruits, how long it runs and how big it is all move the placebo response — and none of that is about the drug. Sat, 08 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/microbiome-causality-mouse-human-gap https://www.healthnewspapers.com/science/microbiome-causality-mouse-human-gap A systematic review in Cell called that rate implausible and said it overstates the gut microbiome's role in human disease. A separate audit found the statistical tools themselves disagree. Sat, 08 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/testosterone-generational-decline https://www.healthnewspapers.com/science/testosterone-generational-decline Two datasets report an age-independent fall in men's testosterone across birth cohorts. A separate study of nine thousand men found much of the variation between cohorts came from the tests themselves. Thu, 06 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/liver-enzymes-alt-ast-blood-test-meaning https://www.healthnewspapers.com/science/liver-enzymes-alt-ast-blood-test-meaning Raised liver enzymes are common and mean the liver may be under strain, not that a disease is confirmed. The pattern, degree and duration of the change are what a clinician reads, not a single flag. Wed, 05 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/sperm-count-decline-contested https://www.healthnewspapers.com/science/sperm-count-decline-contested A 223-study meta-regression reports sperm concentration falling 51.6% since 1973. Two published critiques argue the method cannot support that reading. Both sides are peer-reviewed. Tue, 04 Aug 2026 00:00:00 GMT science https://www.healthnewspapers.com/science/screen-time-young-children-development-evidence https://www.healthnewspapers.com/science/screen-time-young-children-development-evidence Longitudinal data and a meta-analysis of 159,425 children find consistent associations between screen time and development — but the effects are small, observational, and thinner than the guidelines imply. Mon, 03 Aug 2026 00:00:00 GMT science