https://www.healthnewspapers.com/mind Mental health, psychedelics, loneliness, and neuroscience. en-us https://www.healthnewspapers.com/mind/perinatal-depression-infant-mortality-new-jersey https://www.healthnewspapers.com/mind/perinatal-depression-infant-mortality-new-jersey In 415,000 New Jersey births, infants of mothers who screened positive for depression died before age one at more than three times the rate, an association steady across race, income and preterm birth. Fri, 04 Sep 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/serial-ketamine-treatment-resistant-bipolar-depression https://www.healthnewspapers.com/mind/serial-ketamine-treatment-resistant-bipolar-depression In the Ket-BD trial, four IV ketamine infusions over two weeks lowered depression scores more than an active placebo, with no manic switches observed in 63 analysed patients. Thu, 03 Sep 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/nutraceuticals-depression-network-meta-analysis https://www.healthnewspapers.com/mind/nutraceuticals-depression-network-meta-analysis A network meta-analysis of 163 trials found EPA, vitamin D and a St John's wort extract beat placebo by margins so large the researchers treat them as a warning about the evidence, not a green light. Wed, 02 Sep 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/cannabis-edibles-simulated-driving https://www.healthnewspapers.com/mind/cannabis-edibles-simulated-driving In a 40-person crossover trial, 10 mg and 20 mg of edible THC degraded lane-keeping while whole-blood THC peaked at 1.6 and 3.4 ng/mL — near or under the thresholds police enforce. Mon, 31 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/social-media-adolescent-wellbeing-effect-size https://www.healthnewspapers.com/mind/social-media-adolescent-wellbeing-effect-size Two large re-analyses of the same public datasets found the association is real, negative and very small. A third review found the association is not even consistent between the Global North and South. Sun, 30 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/clozapine-neutropenia-monitoring-hong-kong https://www.healthnewspapers.com/mind/clozapine-neutropenia-monitoring-hong-kong In 4,868 clozapine users followed to 2023, excess neutropenia risk concentrated in the first 18 weeks and converged with other antipsychotics by around two years. Sat, 29 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/oddessi-open-dialogue-crisis-care https://www.healthnewspapers.com/mind/oddessi-open-dialogue-crisis-care The ODDESSI trial ran in 30 clusters across five NHS trusts in England. Time to relapse was unchanged; inpatient admission, re-referral and service-user ratings all moved in Open Dialogue's favour. Wed, 26 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/glp1-mortality-serious-mental-illness https://www.healthnewspapers.com/mind/glp1-mortality-serious-mental-illness A 1.5-million-person records study reports lower mortality with GLP-1 drugs than with SGLT2 inhibitors, and the largest absolute gains in people with serious mental illness. The design cannot prove it. Wed, 26 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/childhood-maltreatment-epigenetic-clocks-null https://www.healthnewspapers.com/mind/childhood-maltreatment-epigenetic-clocks-null In 276 adults tested at 60, the differences in GrimAge and DunedinPACE were small, their intervals crossed zero, and most of what was there disappeared once smoking was accounted for. Tue, 25 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/adhd-stimulant-treatment-children-evidence https://www.healthnewspapers.com/mind/adhd-stimulant-treatment-children-evidence The MTA trial randomised 579 children and found medication management clearly superior short-term. Its own long-term follow-up found the treatment groups no longer differed by 6 to 8 years. Tue, 25 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/rapamycin-brain-alzheimers-trials https://www.healthnewspapers.com/mind/rapamycin-brain-alzheimers-trials A ten-person phase 1 study measured whether oral rapamycin reaches the central nervous system in early Alzheimer's. It did not — and several disease biomarkers rose over eight weeks. Mon, 24 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/burnout-condition-versus-metaphor-evidence https://www.healthnewspapers.com/mind/burnout-condition-versus-metaphor-evidence WHO's ICD-11 lists burn-out, yet places it among reasons people contact health services, not among illnesses. It is defined strictly as a workplace phenomenon, which shapes who should be assessing it and how. Mon, 24 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/anxiety-cases-versus-rates-and-diagnosis https://www.healthnewspapers.com/mind/anxiety-cases-versus-rates-and-diagnosis The Global Burden of Disease estimates for anxiety disorders separate two things that public debate keeps merging: how many people have it, and how likely a given person is to. Diagnosis is a third question again. Mon, 24 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psilocybin-context-brain-reorganization-nature https://www.healthnewspapers.com/mind/psilocybin-context-brain-reorganization-nature In 62 adults scanned under psilocybin during rest, meditation, music, and film, brain networks reorganized differently by setting — and more reorganization tracked with more positive experiences. Sun, 23 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/gut-microbiota-causal-depression-study https://www.healthnewspapers.com/mind/gut-microbiota-causal-depression-study Using causal-inference methods on 1,269 people, researchers linked two bacterial genera to depression independent of body weight and medication — the first such evidence in humans, not proof of mechanism. Sun, 23 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/australia-social-media-age-law-how-it-gets-measured https://www.healthnewspapers.com/mind/australia-social-media-age-law-how-it-gets-measured A 422-family cohort with a pre-ban baseline is the closest thing to a controlled test the world has. Researchers are also warning the law will make studying adolescents harder — including studying this. Sat, 22 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/sleep-training-evidence-long-term https://www.healthnewspapers.com/mind/sleep-training-evidence-long-term A randomised trial tracked infants' cortisol and attachment; a five-year follow-up tracked mental health. Graduated extinction improved sleep with no sign of long-term damage — or lasting benefit. Wed, 19 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/mbsr-versus-escitalopram-anxiety-trial https://www.healthnewspapers.com/mind/mbsr-versus-escitalopram-anxiety-trial The TAME trial randomised 276 adults with diagnosed anxiety disorders to mindfulness-based stress reduction or escitalopram. The difference on the primary measure was 0.07 points, inside the noninferiority margin. Wed, 19 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/cognitive-reserve-real-but-hard-to-build https://www.healthnewspapers.com/mind/cognitive-reserve-real-but-hard-to-build Autopsy studies show educated brains carry the same disease but express it as dementia later. That is the concept's strength — and the reason it resists being turned into a to-do list. Tue, 18 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psilocybin-fda-priority-review https://www.healthnewspapers.com/mind/psilocybin-fda-priority-review The agency compressed review of three psychedelic therapies from a year to weeks. A first approval decision is plausible by early 2027. Fri, 14 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/exercise-aging-brain-trial-evidence https://www.healthnewspapers.com/mind/exercise-aging-brain-trial-evidence Observational studies tie fitness to slower cognitive decline. When researchers randomise older adults to exercise, the cognitive payoff shrinks — in a Cochrane review of healthy people, to nothing. Fri, 14 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/which-psychotherapy-for-depression-evidence https://www.healthnewspapers.com/mind/which-psychotherapy-for-depression-evidence A network meta-analysis of 331 trials and 34,285 adults found no significant differences between the main psychotherapies, with one exception. In children and adolescents the picture is narrower. Wed, 12 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/crosswords-reverse-causation-cognitive-decline https://www.healthnewspapers.com/mind/crosswords-reverse-causation-cognitive-decline The link between puzzles and a sharper old age is real in the data and largely the wrong way round: the earliest changes of dementia quietly reduce the very activities that later look protective. Tue, 11 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/brain-training-games-transfer-active-trial https://www.healthnewspapers.com/mind/brain-training-games-transfer-active-trial The best long-term trial found trained skills can last a decade. Whether they transfer to daily life, or hold off dementia, is where the evidence — and the FTC — parted ways with the marketing. Fri, 07 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/therapy-versus-antidepressants-network-meta-analysis https://www.healthnewspapers.com/mind/therapy-versus-antidepressants-network-meta-analysis A network meta-analysis of 101 trials and 11,910 patients found no significant difference between psychotherapy and medication for adult depression — and a consistent advantage for combining them. Wed, 05 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/nociplastic-pain-central-sensitisation-concept https://www.healthnewspapers.com/mind/nociplastic-pain-central-sensitisation-concept Pain medicine added a third mechanistic category in 2017 and has been arguing about it since. There is no test for it, the criteria work by exclusion, and the experts who wrote them say that is a problem. Wed, 05 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/lancet-commission-45-percent-dementia-what-it-means https://www.healthnewspapers.com/mind/lancet-commission-45-percent-dementia-what-it-means A standing commission estimates that eliminating 14 risk factors could prevent or delay 45% of dementia across a whole population. What that number means for one person is a different and much weaker claim. Tue, 04 Aug 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/severe-mental-illness-physical-mortality-gap-europe https://www.healthnewspapers.com/mind/severe-mental-illness-physical-mortality-gap-europe A registry study spanning 4.9 million people separates where the most deaths occur from where the inequality is largest. Heart disease and lung disease give different answers. Tue, 28 Jul 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/mental-health-apps-evidence-availability-gap https://www.healthnewspapers.com/mind/mental-health-apps-evidence-availability-gap A review of 110 studies found that 52% of trialled self-guided apps were publicly available — and that evidence quality had no bearing on which ones made it to an app store. Fri, 24 Jul 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/glp1-alcohol-related-hospitalizations-target-trial https://www.healthnewspapers.com/mind/glp1-alcohol-related-hospitalizations-target-trial Four separate trial emulations, each with a different comparator, all pointed the same direction. The strongest effect appeared among people being treated for alcohol use disorder. Fri, 24 Jul 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/glp1-opioid-use-disorder-rats-to-humans-review https://www.healthnewspapers.com/mind/glp1-opioid-use-disorder-rats-to-humans-review A review lays out the evidence chain: animal studies showing reduced drug-seeking, one small human trial, and record-based analyses linking GLP-1 prescriptions to 40% fewer opioid overdoses. Wed, 22 Jul 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/measurement-based-care-implementation-gap https://www.healthnewspapers.com/mind/measurement-based-care-implementation-gap A systematic review found only 16 usable studies of how to implement routine symptom monitoring in adult mental health services. A 4,778-patient clinic dataset shows what it looks like when it does. Tue, 21 Jul 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/repeat-subcutaneous-ketamine-treatment-resistant-depression-kads https://www.healthnewspapers.com/mind/repeat-subcutaneous-ketamine-treatment-resistant-depression-kads The KADS extension followed 130 patients who had already been through a ketamine trial. Response fell from 30% at treatment's end to 17% a month later. Tue, 07 Jul 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/ketamine-suicidal-depressive-symptoms-meta-analysis https://www.healthnewspapers.com/mind/ketamine-suicidal-depressive-symptoms-meta-analysis The meta-analysis behind ketamine's widening off-label use for suicidal crisis quantifies what 1,166 patients across two decades of trials actually showed — and where the evidence runs out. Thu, 02 Jul 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/loneliness-not-isolation-cognition-mortality https://www.healthnewspapers.com/mind/loneliness-not-isolation-cognition-mortality A registered report fit identical models to 11 longitudinal studies covering 175,070 people. The subjective feeling carried the signal; the objective count of social contacts largely did not. Tue, 30 Jun 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/korea-mental-health-act-emergency-visits https://www.healthnewspapers.com/mind/korea-mental-health-act-emergency-visits A quasi-experimental analysis of 23 hospitals finds about 95 additional self-harm and suicide-related emergency visits a month after the law changed, alongside fewer psychiatric admissions. Thu, 25 Jun 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/transportation-noise-depression-dementia-burden-europe https://www.healthnewspapers.com/mind/transportation-noise-depression-dementia-burden-europe A burden-of-disease calculation built on EU noise-mapping data puts numbers on two outcomes that noise research has mostly ignored. The confidence intervals are as informative as the estimates. Wed, 24 Jun 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/direct-to-consumer-ketamine-evidence-base https://www.healthnewspapers.com/mind/direct-to-consumer-ketamine-evidence-base A systematic review screened 3,857 records and found three eligible studies, every one produced by a US commercial provider and every one at critical risk of bias. Fri, 19 Jun 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/hallucinogen-psychosis-confounded-baseline-psychiatric-history https://www.healthnewspapers.com/mind/hallucinogen-psychosis-confounded-baseline-psychiatric-history In 273,466 people with substance-related hospital admissions, psychosis was far more common after hallucinogen admissions, until adjustment for preexisting conditions erased the link. Mon, 15 Jun 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psilocybin-veterans-anxiety-quality-of-life https://www.healthnewspapers.com/mind/psilocybin-veterans-anxiety-quality-of-life Anxiety, quality of life and PTSD symptoms all improved after a single dose in this 15-person trial. Once researchers accounted for depression improvement, those effects mostly disappeared. Tue, 09 Jun 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/real-world-psilocybin-therapy-switzerland-trd https://www.healthnewspapers.com/mind/real-world-psilocybin-therapy-switzerland-trd Switzerland allows limited psilocybin use for treatment-resistant depression. A review of 19 patients found meaningful improvement, but remission in barely a fifth to a quarter. Wed, 03 Jun 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psychedelic-induced-hypomania-mania-meta-analysis https://www.healthnewspapers.com/mind/psychedelic-induced-hypomania-mania-meta-analysis A review pooling 23 studies found risk concentrated among people with bipolar I disorder, family history, or unsupervised use. About 4% later transitioned to bipolar disorder. Sat, 30 May 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/neurodevelopmental-disorders-south-america-thirty-year-trends https://www.healthnewspapers.com/mind/neurodevelopmental-disorders-south-america-thirty-year-trends A single-author analysis of Global Burden of Disease estimates finds the region's neurodevelopmental picture split in two — and argues the flat autism curve reflects diagnostic capacity, not risk. Fri, 22 May 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psilocybin-chronic-suicidal-ideation-open-label https://www.healthnewspapers.com/mind/psilocybin-chronic-suicidal-ideation-open-label By the study's end, 70% had scores low enough to be considered near-resolution. There was no placebo arm — every participant knew what they'd received. Tue, 19 May 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/episode-psilocybin-treatment-resistant-depression-trial https://www.healthnewspapers.com/mind/episode-psilocybin-treatment-resistant-depression-trial EPISODE randomized 144 people with treatment-resistant depression across four arms. High-dose psilocybin missed its main outcome, even as secondary measures showed symptom benefit. Sat, 16 May 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psilocybin-cocaine-use-disorder-trial https://www.healthnewspapers.com/mind/psilocybin-cocaine-use-disorder-trial No medication has proven effective for cocaine use disorder. A single psilocybin dose, paired with therapy, produced more abstinent days and a longer time to relapse than an active placebo. Sat, 09 May 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psilocybin-major-depression-rapid-effects-trial https://www.healthnewspapers.com/mind/psilocybin-major-depression-rapid-effects-trial In 35 patients with recurrent major depression, psilocybin beat an active placebo through day 42. On self-reported measures the effect lingered further, but the trial's primary endpoint showed no difference at 365 days. Wed, 06 May 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/tsnd-201-methylone-ptsd-phase2-trial https://www.healthnewspapers.com/mind/tsnd-201-methylone-ptsd-phase2-trial TSND-201 improved PTSD severity, disability, and depression scores over placebo in 65 participants — delivered as an oral dose with monitoring but no formal psychotherapy alongside it. Sat, 02 May 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/2cb-mdma-psilocybin-comparison-trial https://www.healthnewspapers.com/mind/2cb-mdma-psilocybin-comparison-trial Twenty-four healthy volunteers received all three drugs in a crossover trial. At 30 mg, 2C-B matched MDMA's intensity and produced psilocybin-like states, without psilocybin's anxiety. Thu, 30 Apr 2026 00:00:00 GMT mind https://www.healthnewspapers.com/mind/psilocybin-past-year-prevalence-us https://www.healthnewspapers.com/mind/psilocybin-past-year-prevalence-us The first federal survey to ask about psilocybin specifically finds 2.8% past-year use, concentrated among young, white, college-educated men. People with recent depression had 37% higher odds. Thu, 23 Apr 2026 00:00:00 GMT mind